Dendritic depolarization efficiently attenuates low-threshold calcium spikes in thalamic relay cells.

@article{Zhan2000DendriticDE,
  title={Dendritic depolarization efficiently attenuates low-threshold calcium spikes in thalamic relay cells.},
  author={Xu-ping Zhan and Charles L. Cox and S. Murray Sherman},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2000},
  volume={20 10},
  pages={3909-14}
}
Thalamic relay cells respond in two distinct modes, burst and tonic, that depend on a voltage-dependent, low-threshold, transient Ca(2+) current (I(T)), and these modes relay different forms of information to cortex. I(T) activation evokes a low-threshold spike (LTS), producing a burst of action potentials. Modulatory inputs from cortex and brainstem are known to activate metabotropic receptors on relay cell dendrites at which the T channels underlying I(T) may be concentrated. We thus… CONTINUE READING