Dendritic cells transduced with viral interleukin 10 or Fas ligand: no evidence for induction of allotolerance in vivo.

@article{Buonocore2002DendriticCT,
  title={Dendritic cells transduced with viral interleukin 10 or Fas ligand: no evidence for induction of allotolerance in vivo.},
  author={Sofia Buonocore and Sonja van Meirvenne and F Demoor and Fr{\'e}d{\'e}ric Paulart and Kris 8 Thielemans and Michel Goldman and V{\'e}ronique H. Flamand},
  journal={Transplantation},
  year={2002},
  volume={73 1 Suppl},
  pages={S27-30}
}
Dendritic cells (DC) are the most potent presenters of alloantigens and therefore are responsible for the induction of allograft rejection. Genetic modifications of DC allowing the expression of a tolerogenic molecule may render them immunosuppressive. We transduced bone marrow-derived DC with recombinant MFG retrovirus encoding either viral interleukin (vIL)-10 or Fas ligand (FasL) to induce transplantation tolerance. Up to 10 ng/ml of bioactive vIL-10 was produced by DC after transfer of the… CONTINUE READING
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