Dendritic cells route human immunodeficiency virus to lymph nodes after vaginal or intravenous administration to mice.

@article{Masurier1998DendriticCR,
  title={Dendritic cells route human immunodeficiency virus to lymph nodes after vaginal or intravenous administration to mice.},
  author={Carole Masurier and Beno{\^i}t L. Salomon and N Gu{\'e}ttari and C Pioche and François Lachapelle and Martine Guigon and David Klatzmann},
  journal={Journal of virology},
  year={1998},
  volume={72 10},
  pages={7822-9}
}
We have developed a murine model to study the involvement of dendritic cells (DC) in human immunodeficiency virus (HIV) routing from an inoculation site to the lymph nodes (LN). Murine bone marrow-derived DC migrate to the draining LN within 24 h after subcutaneous injection. After incubation of these cells with heat-inactivated (Hi) HIV type 1 (HIV-1), HIV RNA sequences were detected in the draining LN only. Upon injection of DC pulsed with infectious HIV, the virus recovered in the draining… CONTINUE READING

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