Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination.

@article{Niel2006DendriticCR,
  title={Dendritic cells regulate exposure of MHC class II at their plasma membrane by oligoubiquitination.},
  author={Guillaume van Niel and Richard W. Wubbolts and Toine ten Broeke and Sonja I. Buschow and Ferry A. Ossendorp and Cornelis J M Melief and Graça Raposo and Bas W. M. van Balkom and Willem Stoorvogel},
  journal={Immunity},
  year={2006},
  volume={25 6},
  pages={885-94}
}
Dendritic cells (DCs) initiate adaptive immune responses by activating T cells via cognate interactions between MHC-peptide complexes and T cell receptors. In immature DCs, MHC class II is predominantly stored in late endocytic compartments, where it has a short half-life because of degradation. In contrast, mature DCs recruit MHC class II to the plasma membrane. We here demonstrate that in immature DCs, the beta-chain of MHC class II was oligoubiquitinated after proteolytic processing of the… CONTINUE READING
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Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments.

Proceedings of the National Academy of Sciences of the United States of America • 2005
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