Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3.

@article{Yu2006DendriticCP,
  title={Dendritic cells pulsed with hepatitis C virus NS3 protein induce immune responses and protection from infection with recombinant vaccinia virus expressing NS3.},
  author={Hong Yu and Hui Huang and Jim Xiang and Lorne A. Babiuk and Sylvia van Drunen Littel-van den Hurk},
  journal={The Journal of general virology},
  year={2006},
  volume={87 Pt 1},
  pages={1-10}
}
Infections with Hepatitis C virus (HCV) pose a serious health problem worldwide. In this study, the hypothesis that adoptive transfer of dendritic cells (DCs) pulsed with HCV NS3 protein and matured with an oligodeoxynucleotide (ODN) containing CpG motifs (CpG) ex vivo would initiate potent HCV-specific protective immune responses in vivo was tested. NS3 protein was efficiently transduced into DCs and treatment of DCs with CpG ODN induced phenotypic maturation and specifically increased the… CONTINUE READING

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