Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo

@article{Boczkowski1996DendriticCP,
  title={Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo},
  author={David Boczkowski and Smita K Nair and David Snyder and Eli Gilboa},
  journal={The Journal of Experimental Medicine},
  year={1996},
  volume={184},
  pages={465 - 472}
}
Immunization with defined tumor antigens is currently limited to a small number of cancers where candidates for tumor rejection antigens have been identified. In this study we investigated whether pulsing dendritic cells (DC) with tumor-derived RNA is an effective way to induce CTL and tumor immunity. DC pulsed with in vitro synthesized chicken ovalbumin (OVA) RNA were more effective than OVA peptide-pulsed DC in stimulating primary, OVA-specific CTL responses in vitro. DC pulsed with… CONTINUE READING