Dendritic cells prime natural killer cells by trans-presenting interleukin 15.

@article{Lucas2007DendriticCP,
  title={Dendritic cells prime natural killer cells by trans-presenting interleukin 15.},
  author={Mathias Lucas and William Schachterle and Karin Oberle and Peter Aichele and Andreas Diefenbach},
  journal={Immunity},
  year={2007},
  volume={26 4},
  pages={
          503-17
        }
}
Natural killer (NK) cells are important effector cells in the control of infections. The cellular and molecular signals required for NK cell activation in vivo remain poorly defined. By using a mouse model for the inducible ablation of dendritic cells (DCs), we showed that the in vivo priming of NK cell responses to viral and bacterial pathogens required the presence of CD11c(high) DCs. After peripheral Toll-like receptor (TLR) stimulation, NK cells were recruited to local lymph nodes, and… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 470 CITATIONS, ESTIMATED 52% COVERAGE

Inducible down-regulation of MHC class I results in natural killer cell tolerance

  • The Journal of experimental medicine
  • 2019
VIEW 12 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED

Type 1 Diabetes and Its Multi-Factorial Pathogenesis: The Putative Role of NK Cells

  • International journal of molecular sciences
  • 2018
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The viral innate immune antagonism and an alternative vaccine design for PRRS virus.

  • Veterinary microbiology
  • 2017
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2007
2019

CITATION STATISTICS

  • 55 Highly Influenced Citations

  • Averaged 24 Citations per year from 2017 through 2019

References

Publications referenced by this paper.
SHOWING 1-10 OF 62 REFERENCES

Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL