Dendritic cells loaded with apoptotic oligodendrocytes as a source of myelin T-cell epitopes in multiple sclerosis.

Abstract

Evidence suggests that T-cell response to myelin basic protein (MBP) plays an important role in multiple sclerosis (MS). However, the mechanism of generation for MBP immunogenic epitopes is unclear. A series of specific CD4(+) T-cell lines was obtained by stimulating peripheral blood mononuclear cells from MS patients with synthetic peptides spanning the… (More)
DOI: 10.1016/j.clim.2008.07.017

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@article{Meloni2008DendriticCL, title={Dendritic cells loaded with apoptotic oligodendrocytes as a source of myelin T-cell epitopes in multiple sclerosis.}, author={Francesca Romana Meloni and Daniele Accapezzato and Cristina Agresti and Francesca Aloisi and Giovanni Ristori and Marco Salvetti and Roberto Furlan and Gianvito Martino and Vincenzo Barnaba and Marino Paroli}, journal={Clinical immunology}, year={2008}, volume={129 2}, pages={286-94} }