Dendritic cells in the thymus contribute to T-regulatory cell induction.

  title={Dendritic cells in the thymus contribute to T-regulatory cell induction.},
  author={Anna I. Proietto and Serani L.H. van Dommelen and Penghui Zhou and Alexandra Rizzitelli and Angela D'Amico and Raymond J Steptoe and Shalin H. Naik and Mireille H. Lahoud and Yang Liu and Pan Zheng and Ken D Shortman and Li Wu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 50},
Central tolerance is established through negative selection of self-reactive thymocytes and the induction of T-regulatory cells (T(R)s). The role of thymic dendritic cells (TDCs) in these processes has not been clearly determined. In this study, we demonstrate that in vivo, TDCs not only play a role in negative selection but in the induction of T(R)s. TDCs include two conventional dendritic cell (DC) subtypes, CD8(lo)Sirpalpha(hi/+) (CD8(lo)Sirpalpha(+)) and CD8(hi)Sirpalpha(lo/-) (CD8(hi… CONTINUE READING