Dendritic cells in chronic myelomonocytic leukaemia

@article{Vuckovic1999DendriticCI,
  title={Dendritic cells in chronic myelomonocytic leukaemia},
  author={Slavica Vuckovic and D. B. Fearnley and Sarah P. Gunningham and Ruth Spearing and William Nigel Patton and Derek N. J. Hart},
  journal={British Journal of Haematology},
  year={1999},
  volume={105}
}
Blood dendritic cells (DC) differentiate in vitro via two separate pathways: either directly from blood DC precursors (DCp) or from CD14+ monocytes. In chronic myelomonocytic leukaemia (CMML) abnormal bone marrow precursors contribute to blood monocyte development but DC development has not been studied previously. Monocytes comprised 60% of blood MNC in 15 CMML patients studied, compared with 20% in 16 age‐matched controls. The increase in blood monocytes was accompanied by a reciprocal… Expand
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