Dendritic cells in chronic myelomonocytic leukaemia

@article{Vuckovic1999DendriticCI,
  title={Dendritic cells in chronic myelomonocytic leukaemia},
  author={Slavica Vuckovic and D. B. Fearnley and Sarah P. Gunningham and Ruth Spearing and William Nigel Patton and Derek N. J. Hart},
  journal={British Journal of Haematology},
  year={1999},
  volume={105}
}
Blood dendritic cells (DC) differentiate in vitro via two separate pathways: either directly from blood DC precursors (DCp) or from CD14+ monocytes. In chronic myelomonocytic leukaemia (CMML) abnormal bone marrow precursors contribute to blood monocyte development but DC development has not been studied previously. Monocytes comprised 60% of blood MNC in 15 CMML patients studied, compared with 20% in 16 age‐matched controls. The increase in blood monocytes was accompanied by a reciprocal… 

Phenotypic and functional deficiencies of leukaemic dendritic cells from patients with chronic myeloid leukaemia

Data indicated that the maturation response of leukaemic monocyte‐derived DC to a natural stimulus like LPS is abnormal and may be caused by an aberrant TNF‐α response in these cells, and TNF-α alone or in combination with pro‐inflammatory and T‐cell stimulatory cytokines should be considered as an adjuvant for DC‐based immunotherapy in CML.

Circulating blood dendritic cells from myeloid leukemia patients display quantitative and cytogenetic abnormalities as well as functional impairment.

Evidence is provided that DC subsets in vivo may be affected by leukemogenesis and may contribute to leukemia escape from immune control.

Generation of Dendritic Cells from Human Chronic Myelomonocytic Leukemia Cells in Fetal Calf Serum-Free Medium

It is demonstrated that peripheral blood cells of patients with chronic myelomonocytic leukemia can be induced to acquire DC characteristics and generation of CMML-derived DCs may be used as a cellular vaccine to induce anti-tumor immunity in patients with CMML.

Capacity of Monocytes from Patients with Chronic Myelomonocytic Leukemia to Differentiate into Macrophages and Multinucleated Giant Cells

CMML-Mo could generate dendritic cells (DC), but not multinucleated giant cells (MGC) and the ability to differentiate into MΦ and MGC, but not DC, is suggested.

The effect of LIGHT in inducing maturation of monocyte-derived dendritic cells from MDS patients

It is concluded that both LIGHT and CD40L are immunoregulating factors that induce monocyte-derived iDCs from MDS patients to undergo maturation resulting in increased antigen presentation and T-cell activation.

CD1c(+) myeloid dendritic cells in myeloid neoplasia

Findings indicate CD1c(+) MDC elevations are not uncommon in myeloid leukemias and are associated with CMML and AML, particularly AML with inv(16) cytogenetic abnormality.

Circulating myeloid and lymphoid precursor dendritic cells are clonally involved in myelodysplastic syndromes

Data suggest that myeloid and lymphoid pDC share a common precursor, and whether reduced peripheral blood counts of pDC contribute to the immunological abnormalities observed in MDS remains to be investigated.

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