Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts.

@article{Gabrilovich1996DendriticCI,
  title={Dendritic cells in antitumor immune responses. I. Defective antigen presentation in tumor-bearing hosts.},
  author={Dmitry I Gabrilovich and Ilja Frank Ciernik and David Paul Carbone},
  journal={Cellular immunology},
  year={1996},
  volume={170 1},
  pages={101-10}
}
Induction of specific antitumor cytotoxic T cell responses was studied in BALB/c mice bearing tumors transfected with a mutant human p53 minigene. We observed that mice were resistant to the induction of peptide-specific CTL as early as 5 days after challenge with a minimal lethal dose of tumor cells, and the cell types responsible for this effect were further characterized. The contribution of CD4+ and CD8+ T cells in this response was studied after peptide-pulsed dendritic cell (DC… CONTINUE READING

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