Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection.

@article{Bierly2008DendriticCE,
  title={Dendritic cells expressing plasmacytoid marker PDCA-1 are Trojan horses during Toxoplasma gondii infection.},
  author={Allison L Bierly and William J. Shufesky and Woraporn Sukhumavasi and Adrian E Morelli and Eric Y. Denkers},
  journal={Journal of immunology},
  year={2008},
  volume={181 12},
  pages={8485-91}
}
Plasmacytoid dendritic cells (pDCs) play a key role in the innate immune response to viral infection, due largely to their ability to produce large quantities of type I IFNs. These cells are also notable for their ability to differentiate into conventional dendritic cells after appropriate stimulation. Here, we show that a splenic population of murine CD11c(+) cells expressing pDC markers Gr-1, B220, and PDCA-1 is preferentially parasitized after infection with the virulent RH strain of… CONTINUE READING

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