Dendritic cells expand Epstein Barr virus specific CD8+ T cell responses more efficiently than EBV transformed B cells.

@article{Subklewe2005DendriticCE,
  title={Dendritic cells expand Epstein Barr virus specific CD8+ T cell responses more efficiently than EBV transformed B cells.},
  author={Marion Subklewe and Kathrin Sebelin and Andrea Block and Antje Meier and Anna H E Roukens and Casper Paludan and J Fonteneau and Ralph Marvin Steinman and Christian M{\"u}nz},
  journal={Human immunology},
  year={2005},
  volume={66 9},
  pages={938-49}
}
Adoptive transfer of Epstein Barr virus (EBV) specific cytotoxic T lymphocytes (CTLs) has been successfully applied in the treatment of EBV associated post-transplant lymphoproliferative disease (PTLD). In most studies EBV transformed B cells (LCLs) have been used for the induction of EBV specific T cell lines. Application of this approach to other EBV associated tumors is difficult, because LCLs focus T cell expansion toward immunodominant EBV antigens that are not expressed in EBV associated… CONTINUE READING

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