Dendritic cells dysfunction in tumour environment.

@article{Bennaceur2008DendriticCD,
  title={Dendritic cells dysfunction in tumour environment.},
  author={Karim Bennaceur and Jessica Alice Chapman and Leila Brikci-Nigassa and Kamel Sanhadji and Jean-louis Touraine and Jacques Portoukalian},
  journal={Cancer letters},
  year={2008},
  volume={272 2},
  pages={186-96}
}
Several studies indicate that most tumours are immunogenic and they rarely succeed to induce an efficient immune response. Many mechanisms have been involved in the tumour escape from host immune surveillance. The tumour microenvironment has emerged as an important component contributing to dendritic cells (DCs) dysfunction. There is evidence that DCs play a key role in the induction of tumour-specific immune responses, especially via cross-priming through MHC-class I antigens presentation. In… CONTINUE READING

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