Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response.

@article{Floh2006DendriticCD,
  title={Dendritic cells during polymicrobial sepsis rapidly mature but fail to initiate a protective Th1-type immune response.},
  author={Stefanie B. Floh{\'e} and Hemant Agrawal and Daniel C Schmitz and Michaela Gertz and Sascha Floh{\'e} and Fritz Ulrich Schade},
  journal={Journal of leukocyte biology},
  year={2006},
  volume={79 3},
  pages={
          473-81
        }
}
Polymicrobial sepsis is associated with immunosuppression caused by the predominance of anti-inflammatory mediators and profound loss of lymphocytes through apoptosis. Dendritic cells (DC) are potent antigen-presenting cells and play a key role in T cell activation. We tested the hypothesis that DC are involved in sepsis-mediated immunosuppression in a mouse cecal ligation and puncture (CLP) model, which resembles human polymicrobial sepsis. At different time-points after CLP, DC from the… CONTINUE READING

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