Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4.

@article{Ricart2011DendriticCD,
  title={Dendritic cells distinguish individual chemokine signals through CCR7 and CXCR4.},
  author={Brendon Guenther Ricart and Beena John and Dooyoung Lee and Christopher A Hunter and Daniel A. Hammer},
  journal={Journal of immunology},
  year={2011},
  volume={186 1},
  pages={53-61}
}
Dendritic cells (DCs) respond to chemotactic signals to migrate from sites of infection to secondary lymphoid organs where they initiate the adaptive immune response. The key chemokines directing their migration are CCL19, CCL21, and CXCL12, but how signals from these chemokines are integrated by migrating cells is poorly understood. Using a microfluidic device, we presented single and competing chemokine gradients to murine bone-marrow derived DCs in a controlled, time-invariant… CONTINUE READING