Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss.

@article{Alnaeeli2007DendriticCA,
  title={Dendritic cells at the osteo-immune interface: implications for inflammation-induced bone loss.},
  author={Mawadda Alnaeeli and Jaekweon Park and Deeqa A. Mahamed and Joseph M. Penninger and Yen-Tung Andy Teng},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2007},
  volume={22 6},
  pages={775-80}
}
Within the past decade, the critical roles of T cells and T cell-mediated immunity in inflammation-induced osteoclastogenesis and subsequent bone loss have been extensively studied, thereby establishing the new paradigm of osteoimmunology. Therefore, dendritic cells (DCs), the most potent antigen-presenting cells, responsible for activation of naïve T cells and orchestration of the immune response, became critically situated at the osteo-immune interface. Today, emerging new evidence suggests… CONTINUE READING

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