Dendritic cells as targets for therapy in rheumatoid arthritis

@article{Khan2009DendriticCA,
  title={Dendritic cells as targets for therapy in rheumatoid arthritis},
  author={Shaukat Hyat Khan and Jeffrey David Greenberg and Nina Bhardwaj},
  journal={Nature Reviews Rheumatology},
  year={2009},
  volume={5},
  pages={566-571}
}
Dendritic cells (DCs) are central in inducing immunity and in mediating immune tolerance in their role as professional antigen-presenting cells. In the absence of DCs, a fatal autoimmunity develops in animal models. Although the role of DCs has been investigated extensively in the pathogenesis of rheumatoid arthritis (RA), it remains unclear whether DCs initiate autoimmunity in this disease. Nevertheless, evidence points towards a significant role for DCs in disease maintenance and progression… CONTINUE READING

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