Dendritic cells as potential targets for mucosal immunotherapy.

  title={Dendritic cells as potential targets for mucosal immunotherapy.},
  author={J P Allam and Thomas Bieber and Natalija Novak},
  journal={Current opinion in allergy and clinical immunology},
  volume={9 6},
PURPOSE OF REVIEW A recent meta-analysis confirmed that sublingual immunotherapy represents a safe and efficient alternative to traditional subcutaneous immunotherapy in the treatment of allergic rhinitis. However, the immunological mechanisms have not been elucidated in detail yet. The current concept postulates a Th2/Th1 shift along with tolerance induction. Without doubt, oral mucosal antigen-presenting cells such as dendritic cells play a central role as they process antigens to initialize… CONTINUE READING


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CCR 7 - CCL 19 / CCL 21 - regulated dendritic cells are responsible for effectiveness of sublingual vaccination

  • JH Song, JI Kim, HJ Kwon
  • J Immunol
  • 2009

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