Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands.

  title={Dendritic cells as key targets for immunomodulation by Vitamin D receptor ligands.},
  author={L. Adorini and Giuseppe Penna and Nadia Giarratana and Andrea Roncari and Susana Amuchastegui and Kenn Curt Daniel and Milan R. Uskokovi{\'c}},
  journal={The Journal of steroid biochemistry and molecular biology},
  volume={89-90 1-5},
Vitamin D receptor (VDR) ligands, in addition to controlling calcium metabolism, exert important effects on the growth and differentiation of many cell types and possess pronounced pro-tolerogenic immunoregulatory activities. VDR ligands can act directly on T cells, but antigen-presenting cells (APCs), and in particular dendritic cells (DCs), appear to be primary targets for their tolerogenic properties. The capacity of VDR ligands to target APCs and T cells is mediated by VDR expression in… CONTINUE READING

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