Dendritic cells as host cells for the promastigote and amastigote stages of Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation.

@article{Prina2004DendriticCA,
  title={Dendritic cells as host cells for the promastigote and amastigote stages of Leishmania amazonensis: the role of opsonins in parasite uptake and dendritic cell maturation.},
  author={Eric Prina and Sofiane Zaki Abdi and Ma{\"i} Lebastard and Emmanuelle Perret and Nathalie Winter and J C Antoine},
  journal={Journal of cell science},
  year={2004},
  volume={117 Pt 2},
  pages={315-25}
}
In their mammalian hosts, Leishmania are obligate intracellular parasites that mainly reside in macrophages. They are also phagocytosed by dendritic cells (DCs), which play decisive roles in the induction and shaping of T cell-dependent immune responses. Little is known about the role of DCs in the Leishmania life cycle. Here, we examined the ability of mouse bone marrow-derived DCs to serve as hosts for L. amazonensis. Both infective stages of Leishmania (metacyclic promastigotes and… CONTINUE READING
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