Dendritic cells are dysfunctional in patients with operable breast cancer

  title={Dendritic cells are dysfunctional in patients with operable breast cancer},
  author={Sukchai Satthaporn and Adrian R. Robins and Wichai Vassanasiri and Mohamed A El-Sheemy and Jibril Ahmad Jibril and David T. Clark and David Valerio and O. G. Eremin},
  journal={Cancer Immunology, Immunotherapy},
Background: Dendritic cells (DCs) play a crucial role in presenting antigens to T lymphocytes and inducing cytotoxic T cells. DCs have been studied in patients with breast cancer to define the factors leading to failure of an effective systemic and locoregional anticancer host response. Methods: Purified DCs were obtained from peripheral blood (PB) and lymph nodes (LNs) of women with operable breast cancer, using immunomagnetic bead selection. The stimulatory capacity of DCs in the allogeneic… CONTINUE READING
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Mononuclear phagocytes but not tumour cells are the main source of elevated interleukin (IL)-10 levels in human breast cancer

  • B Al-Sarireh, O Robins, O Eremin
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