Dendritic cells and the control of immunity

  title={Dendritic cells and the control of immunity},
  author={Jacques F. Banchereau and Ralph M. Steinman},
B and T lymphocytes are the mediators of immunity, but their function is under the control of dendritic cells. Dendritic cells in the periphery capture and process antigens, express lymphocyte co-stimulatory molecules, migrate to lymphoid organs and secrete cytokines to initiate immune responses. They not only activate lymphocytes, they also tolerize T cells to antigens that are innate to the body (self-antigens), thereby minimizing autoimmune reactions. Once a neglected cell type, dendritic… 
Dendritic Cell Subsets and Immune Regulation
Dendritic cells represent a dynamic network in the immune system and can collect and process antigens for presentation to T cells, which provide great potential for designing more effective vaccines and new therapies for the treatment of cancer and other immune-related diseases through targeting the DC.
The instructive role of dendritic cells on T-cell responses
It is discussed how the nature of the DC maturation stimuli and the density and quality of DCs present in the T-cell areas of secondary lymphoid organs determine the magnitude and class of theT-cell response.
The Central Role of Dendritic Cells in Immunity
The following section will review the many diverse subsets of both human and mouse dendritic cells and the phenotypic and functional changes they undergo following antigen exposure and the dendrite cell-directed T-cell differentiation will be discussed.
Dendritic Cells
  • K. Liu
  • Biology
    Encyclopedia of Cell Biology
  • 2016
Dendritic cells
Clinical studies have shown promise in the use of antigen‐pulsed autologous DC for vaccination of cancer patients and in preventing rejection after transplantation, immunization against viral infections and immunosuppression in autoimmune diseases.
Dendritic cell subsets in health and disease
It is proposed that interstitial (dermal) DCs preferentially activate humoral immunity, whereas Langerhans cells preferential induce cellular immunity.
Dendritic cells and cytokines in immune rejection of cancer.
Dynamics of T lymphocyte responses: intermediates, effectors, and memory cells.
How the dynamics of DC-T cell encounter and the mechanism of T cell differentiation make the decoding of this information stochastic rather than determinate results in the generation of both terminally differentiated effector cells and intermediates that play distinctive roles in protection, immunoregulation, and immunological memory is discussed.


A dendritic-cell-derived C–C chemokine that preferentially attracts naive T cells
The specific expression of DC-CK1 by dendritic cells at the site of initiation of an immune response, combined with its chemotactic activity for naive T cells, suggests that DC- cK1 has an important rule in the induction of immune responses.
GM-CSF and TNF-α cooperate in the generation of dendritic Langerhans cells
It is demonstrated that cooperation between GM-CSF and tumour necrosis factor-α (TNF-α) is crucial for the generation of human dendritic/Langerhans cells from CD34+ haematopoietic progenitors.
GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells.
It is demonstrated that cooperation between GM-CSF and tumour necrosis factor-alpha (TNF-alpha) is crucial for the generation of human dendritic/Langerhans cells from CD34+ haematopoietic progenitors.
Dendritic Cells Enhance Growth and Differentiation of CD40-activated B Lymphocytes
In the presence of DC, naive sIgD+ B cells produced, in response to interleukin-2, large amounts of IgM, suggesting that in addition to activating naive T cells in the extrafollicular areas of secondary lymphoid organs, DC may directly modulate B cell growth and differentiation.
Small amounts of superantigen, when presented on dendritic cells, are sufficient to initiate T cell responses
Qualitative aspects underlying the stimulation of human blood T cells by a bacterial superantigen, staphylococcal enterotoxin A (SEA), are described and suggest new roles for MHC class II on dendritic cells, especially the capture and retention of ligands at low external concentrations.
Dendritic cells capable of stimulating T cells in germinal centres
This work has identified a subset of CD4+CD11c+CD3− dendritic cells in the germinal centres that are strong antigen-presenting cells for T cells, but do not co-stimulate CD40-activated B cells.
A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
RANK and RANKL seem to be important regulators of interactions between T cells and dendritic cells.
Dendritic cells acquire antigen from apoptotic cells and induce class I-restricted CTLs
It is shown that human dendritic cells, but not macrophages, efficiently present antigen derived from apoptotic cells, stimulating class I-restricted CD8+ CTLs, suggesting a mechanism by which potent APCs acquire antigens from tumours, transplants, infected cells, or even self-tissue, for stimulation or tolerization of C TLs.
Influenza virus-infected dendritic cells stimulate strong proliferative and cytolytic responses from human CD8+ T cells.
It is found that strong CD8+ CTL responses to influenza virus can be generated from freshly isolated blood T cells, as long as dendritic cells are used as antigen presenting cells (APCs), and the results illustrate the principle that efficient T cell-mediated responses develop in two stages.
The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing
DEC-205 is a novel endocytic receptor that can be used by dendritic cells and thymic epithelial cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment.