Dendritic cells and follicular dendritic cells express a novel ligand for CD38 which influences their maturation and antibody responses.

@article{Wykes2004DendriticCA,
  title={Dendritic cells and follicular dendritic cells express a novel ligand for CD38 which influences their maturation and antibody responses.},
  author={Michelle N. Wykes and Lynette Beattie and Gordon G Macpherson and Derek N J Hart},
  journal={Immunology},
  year={2004},
  volume={113 3},
  pages={318-27}
}
CD38 is a cell surface molecule with ADP-ribosyl cyclase activity, which is predominantly expressed on lymphoid and myeloid cells. CD38 has a significant role in B-cell function as some anti-CD38 antibodies can deliver potent growth and differentiation signals, but the ligand that delivers this signal in mice is unknown. We used a chimeric protein of mouse CD38 and human immunogobulin G (IgG) (CD38-Ig) to identify a novel ligand for murine CD38 (CD38L) on networks of follicular dendritic cells… CONTINUE READING

Similar Papers

Loading similar papers…