Dendritic cells: from ignored cells to major players in T-cell-mediated immunity.

@article{Schuler1997DendriticCF,
  title={Dendritic cells: from ignored cells to major players in T-cell-mediated immunity.},
  author={Gerold Schuler and Beatrice Thurner and Nikolaus Romani},
  journal={International archives of allergy and immunology},
  year={1997},
  volume={112 4},
  pages={317-22}
}
Dendritic cells form a system of leukocytes specialized to stimulate resting T cells in vivo. Dendritic cells are crucial for the initiation of primary immune responses of both helper and cytotoxic T lymphocytes, and thus act as 'nature's adjuvant'. The manifold specializations underlying this in vivo immunostimulatory function are becoming increasingly clear. Methods have been developed to generate large numbers of dendritic cells from hematopoietic precursors in vitro. These techniques now… CONTINUE READING