Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection.

@article{Gorak1998DendriticCB,
  title={Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection.},
  author={P M Gorak and Christian R Engwerda and Paul M. Kaye},
  journal={European journal of immunology},
  year={1998},
  volume={28 2},
  pages={687-95}
}
Infection with Leishmania, an obligate intracellular parasite of mononuclear phagocytes, stimulates the production of IFN-gamma from NK cells, via a pathway which is dependent upon IL-12 and IL-2. IL-12 is also essential for the development of host protective T cell responses to this parasite. However, previous in vitro studies have indicated that macrophages fail to make IL-12 following infection with Leishmania, and that subsequent to infection, macrophages become refractory to normal IL-12… CONTINUE READING

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