Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment.

@article{Liau2005DendriticCV,
  title={Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment.},
  author={L M Liau and Robert M. Prins and Sylvia M. Kiertscher and Sylvia K. Odesa and Thomas J. Kremen and Adrian J. Giovannone and J. Lin and Dennis J. Chute and Paul Mischel and Timothy F. Cloughesy and Michael D Roth},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 15},
  pages={5515-25}
}
PURPOSE We previously reported that autologous dendritic cells pulsed with acid-eluted tumor peptides can stimulate T cell-mediated antitumor immune responses against brain tumors in animal models. As a next step in vaccine development, a phase I clinical trial was established to evaluate this strategy for its feasibility, safety, and induction of systemic and intracranial T-cell responses in patients with glioblastoma multiforme. EXPERIMENTAL DESIGN Twelve patients were enrolled into a… CONTINUE READING
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