Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge.

@article{Mohamadzadeh2009DendriticCT,
  title={Dendritic cell targeting of Bacillus anthracis protective antigen expressed by Lactobacillus acidophilus protects mice from lethal challenge.},
  author={Mansour Mohamadzadeh and Tarn Duong and Sarah J. Sandwick and Tiffanie Hoover and Todd Robert Klaenhammer},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 11},
  pages={
          4331-6
        }
}
Efficient vaccines potentiate antibody avidity and increase T cell longevity, which confer protection against microbial lethal challenge. A vaccine strategy was established by using Lactobacillus acidophilus to deliver Bacillus anthracis protective antigen (PA) via specific dendritic cell-targeting peptides to dendritic cells (DCs), which reside in the periphery and mucosal surfaces, thus directing and regulating acquired immunity. The efficiency of oral delivery of L. acidophilus expressing a… CONTINUE READING
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