Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.

@article{Floto2006DendriticCS,
  title={Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.},
  author={R Andres Floto and Paul A MacAry and Jessica M. Boname and Tan Suet Mien and Beate Kampmann and James R. Hair and Oh Seen Huey and Edith N G Houben and Jean Pieters and Cheryl Day and Wulf Oehlmann and Mahavir Singh and Kenneth G C Smith and Paul J Lehner},
  journal={Science},
  year={2006},
  volume={314 5798},
  pages={454-8}
}
An effective host immune response to mycobacterial infection must control pathogen dissemination without inducing immunopathology. Constitutive overexpression of mycobacterial heat shock protein (myHsp70) is associated with impaired bacterial persistence, but the immune-mediated mechanisms are unknown. We found that myHsp70, in addition to enhancing antigen delivery to human dendritic cells, signaled through the CCR5 chemokine receptor, promoting dendritic cell aggregation, immune synapse… CONTINUE READING
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Dendritic cell stimulation by mycobacterial HSP70 is mediated through the HIV co-receptor CCR5

  • RA Floto, PA MacAry, JM Boname
  • Science
  • 2006

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