Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.

@article{Ramalingam2012DendriticCD,
  title={Dendritic cell-specific disruption of TGF-β receptor II leads to altered regulatory T cell phenotype and spontaneous multiorgan autoimmunity.},
  author={Rajalakshmy Ramalingam and Claire B. Larmonier and Robert D. Thurston and Monica T. Midura-Kiela and Song Guo Zheng and Fayez K. Ghishan and Pawel R. Kiela},
  journal={Journal of immunology},
  year={2012},
  volume={189 8},
  pages={
          3878-93
        }
}
  • Rajalakshmy Ramalingam, Claire B. Larmonier, +4 authors Pawel R. Kiela
  • Published in Journal of immunology 2012
  • Biology, Medicine
  • In vitro data and transgenic mouse models suggest a role for TGF-β signaling in dendritic cells (DCs) to prevent autoimmunity primarily through maintenance of DCs in their immature and tolerogenic state characterized by low expression of MHC class II (MHCII) and costimulatory molecules and increased expression of IDO, among others. To test whether a complete lack of TGF-β signaling in DCs predisposes mice to spontaneous autoimmunity and to verify the mechanisms implicated previously in vitro… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 62 CITATIONS, ESTIMATED 51% COVERAGE

    Regulation of Innate and Adaptive Immunity by TGFβ.

    VIEW 9 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    TGF-β Signaling in Dendritic Cells Governs Colonic Homeostasis by Controlling Epithelial Differentiation and the Luminal Microbiota.

    VIEW 4 EXCERPTS
    CITES RESULTS, BACKGROUND & METHODS
    HIGHLY INFLUENCED

    TGF-β activation and function in immunity.

    VIEW 8 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    The Cytokine TGF‐&bgr; Promotes the Development and Homeostasis of Alveolar Macrophages

    VIEW 5 EXCERPTS
    CITES BACKGROUND
    HIGHLY INFLUENCED

    FILTER CITATIONS BY YEAR

    2013
    2019

    CITATION STATISTICS

    • 4 Highly Influenced Citations

    • Averaged 10 Citations per year from 2017 through 2019