Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes.

@article{Benvenuti2004DendriticCM,
  title={Dendritic cell maturation controls adhesion, synapse formation, and the duration of the interactions with naive T lymphocytes.},
  author={Federica Benvenuti and C{\'e}cile Lagaudri{\`e}re-Gesbert and Isabelle Grandjean and Carolina Cristina Jancic and Claire Hivroz and Alain Trautmann and Olivier Lantz and S{\'e}bastian Amigorena},
  journal={Journal of immunology},
  year={2004},
  volume={172 1},
  pages={292-301}
}
The initiation of adaptive immune responses requires the direct interaction of dendritic cells (DCs) with naive T lymphocytes. It is well established that the maturation state of DCs has a critical impact on the outcome of the response. We show here that mature DCs form stable conjugates with naive T cells and induce the formation of organized immune synapses. Immature DCs, in contrast, form few stable conjugates with no organized immune synapses. A dynamic analysis revealed that mature DCs can… CONTINUE READING

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