Dendritic cell lineage commitment is instructed by distinct cytokine signals.

  title={Dendritic cell lineage commitment is instructed by distinct cytokine signals.},
  author={Kristin Ser{\'e} and Qiong Lin and Piritta Felker and Nina Rehage and Theresa Klisch and Inga Ortseifer and Thomas A. Hieronymus and Stefan Rose-John and Martin Zenke},
  journal={European journal of cell biology},
  volume={91 6-7},
Dendritic cells (DC) develop from hematopoietic stem cells, which is guided by instructive signals through cytokines. DC development progresses from multipotent progenitors (MPP) via common DC progenitors (CDP) into DC. Flt3 ligand (Flt3L) signaling via the Flt3/Stat3 pathway is of pivotal importance for DC development under steady state conditions. Additional factors produced during steady state or inflammation, such as TGF-β1 or GM-CSF, also influence the differentiation potential of MPP and… CONTINUE READING
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