Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting

  title={Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting},
  author={Paul Tacken and I. D. De Vries and Ruurd Torensma and Carl G. Figdor},
  journal={Nature Reviews Immunology},
The realization that dendritic cells (DCs) orchestrate innate and adaptive immune responses has stimulated research on harnessing DCs to create more effective vaccines. Early clinical trials exploring autologous DCs that were loaded with antigens ex vivo to induce T-cell responses have provided proof of principle. Here, we discuss how direct targeting of antigens to DC surface receptors in vivo might replace laborious and expensive ex vivo culturing, and facilitate large-scale application of DC… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS