Dendritic cell homeostasis in the regulation of self-reactivity.

  title={Dendritic cell homeostasis in the regulation of self-reactivity.},
  author={Burkhard Ludewig and Philippe Krebs and Tobias Junt and Gennady Bocharov},
  journal={Current pharmaceutical design},
  volume={9 3},
Dendritic cells (DC) are known for their remarkable ability to induce specific T cell responses. However, the existing views on the role of DC in maintaining tolerance to self-antigens and induction of autoimmunity are somewhat controversial especially when the basic physiology of DC migration, function and homeostasis is considered. This review attempts to provide a comprehensive overview on these topics with particular emphasis on DC homeostasis and presents implications for the generation of… CONTINUE READING