Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection.

@article{Wiethe2008DendriticCD,
  title={Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection.},
  author={Carsten Wiethe and Andrea Debus and Markus Mohrs and Alexander Steinkasserer and Manfred Paul Lutz and Andr{\'e} Gessner},
  journal={Journal of immunology},
  year={2008},
  volume={180 7},
  pages={4371-81}
}
Recent reports demonstrated that dendritic cells (DC) sense inflammatory and microbial signals differently, redefining their classical subdivision into an immature endocytic and a mature Ag-presenting differentiation stage. Although both signals induce DC maturation by up-regulating MHC class II and costimulatory molecules, only TLR signals such as LPS are able to trigger proinflammatory cytokine secretion by DCs, including Th1-polarizing IL-12. Here, we explored the murine Leishmania major… CONTINUE READING

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