Dendritic cell differentiation signals induce anti-inflammatory properties in human adult microglia.

@article{Lambert2008DendriticCD,
  title={Dendritic cell differentiation signals induce anti-inflammatory properties in human adult microglia.},
  author={Caroline M Lambert and Julie Desbarats and Nathalie Arbour and Jeffery A. Hall and Andre Olivier and Amit Bar-Or and Jack P. Antel},
  journal={Journal of immunology},
  year={2008},
  volume={181 12},
  pages={8288-97}
}
Microglia are resident cells of the CNS that belong to the myeloid cell lineage. In experimental models of neuroinflammation, they have limited capacity to function as APCs when compared with dendritic cells (DCs). Human peripheral blood monocytes have the plasticity to differentiate into mature DCs when exposed to GM-CSF and IL-4 followed by LPS. In this study we addressed the potential of human microglia to acquire phenotypic and functional properties of mature DCs under similar inducing… CONTINUE READING
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