Dendritic cell-derived exosomes carry the major cat allergen Fel d 1 and induce an allergic immune response.

@article{Vallhov2015DendriticCE,
  title={Dendritic cell-derived exosomes carry the major cat allergen Fel d 1 and induce an allergic immune response.},
  author={Helen Vallhov and Cindy Gutzeit and Kjell R Hultenby and Rudolf Valenta and Hans Gr{\"o}nlund and A Scheynius},
  journal={Allergy},
  year={2015},
  volume={70 12},
  pages={1651-5}
}
Exosomes are nano-sized membrane vesicles (50-120 nm), which are released from a wide variety of cells. Depending on their cellular origin, they can induce immune stimulatory-, inhibitory-, or tolerance-inducing effects. However, it is still unclear what role exosomes play during human inflammatory diseases. It has not been studied whether exosomes derived from human dendritic cells (DCs), the first cells to encounter allergens in the mucosa, can carry aeroallergens and contribute to allergic… CONTINUE READING