Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin.

@article{McLachlan2009DendriticCA,
  title={Dendritic cell antigen presentation drives simultaneous cytokine production by effector and regulatory T cells in inflamed skin.},
  author={James B. McLachlan and Drew M. Catron and James J Moon and Marc K Jenkins},
  journal={Immunity},
  year={2009},
  volume={30 2},
  pages={277-88}
}
Effector (Teff) and regulatory (Treg) T cells produce cytokines that balance immunity and immunopathology at sites of infection. It is not known how this balance is achieved. Here, we show that Treg and Teff cells specific for the same foreign peptide:major histocompatibility complex II (pMHCII) ligand accumulated preferentially in a subcutaneous site injected with the relevant antigen plus an adjuvant. Some of the Treg cells in this site were producing IL-10 12 days after injection, whereas a… CONTINUE READING

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