Dendritic cell anergy results from endotoxemia in severe malnutrition.

  title={Dendritic cell anergy results from endotoxemia in severe malnutrition.},
  author={Stephen Miles Hughes and Beatrice C Amadi and Mwiya Mwiya and Hope C Nkamba and Andrew Tomkins and David Goldblatt},
  journal={Journal of immunology},
  volume={183 4},
Malnutrition predicts an increased risk of morbidity and mortality from infection. Defects in cell-mediated immunity, such as thymic atrophy, impaired cutaneous tuberculin responses, and reduced T cell mitogenesis in vitro, are well characterized. There has been no convincing mechanism proposed for these T cell defects. However, as T cell responses rely on signals received from APCs, this study evaluates dendritic cell (DC) function in children with severe malnutrition. Repeated sampling of… CONTINUE READING