Dendritic cell activating peptides induce distinct cytokine profiles.


High-mobility group box 1 protein (HMGB1), a DNA-binding nuclear and cytosolic protein, is a pro-inflammatory cytokine released by monocytes and macrophages. HMGB1 as well as its B box domain induce maturation of human dendritic cells (DCs). This report demonstrates that the B box domain induces phenotypic maturation of murine bone marrow-derived dendritic… (More)


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@article{Telusma2006DendriticCA, title={Dendritic cell activating peptides induce distinct cytokine profiles.}, author={Gloria Telusma and Sandip K Datta and Ivan Mihajlov and Wenxue Ma and Jianhua Li and Huan Yang and Walter Newman and Bradley T. Messmer and Boris R. Minev and Ingo G. H. Schmidt-Wolf and Kevin J Tracey and Nicholas Chiorazzi and Davorka Messmer}, journal={International immunology}, year={2006}, volume={18 11}, pages={1563-73} }