Dendritic calcium encodes striatal neuron output during up-states.

  title={Dendritic calcium encodes striatal neuron output during up-states.},
  author={Jason N. D. Kerr and Dietmar Plenz},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={22 5},
Striatal spiny projection neurons control basal ganglia outputs via action potential bursts conveyed to the globus pallidus and substantia nigra. Accordingly, burst activity in these neurons contributes importantly to basal ganglia function and dysfunction. These bursts are driven by multiple corticostriatal inputs that depolarize spiny projection neurons from their resting potential of approximately -85 mV, which is the down-state, to a subthreshold up-state of -55 mV. To understand dendritic… CONTINUE READING
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