Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.

  title={Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy.},
  author={Rosa Cossart and C{\'e}line Dinocourt and June C. Hirsch and Angel Merch{\'a}n-P{\'e}rez and Javier De Felipe and Yehezkiel Ben-Ari and Monique Esclapez and Christophe Bernard},
  journal={Nature neuroscience},
  volume={4 1},
Impaired inhibition is thought to be important in temporal lobe epilepsy (TLE), the most common form of epilepsy in adult patients. We report that, in experimental TLE, spontaneous GABAergic inhibition was increased in the soma but reduced in the dendrites of pyramidal neurons. The former resulted from the hyperactivity of somatic projecting interneurons, whereas the latter was probably due to the degeneration of a subpopulation of dendritic projecting interneurons. A deficit in dendritic… CONTINUE READING
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