Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis.

  title={Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis.},
  author={Bing Zhu and L. Luo and G. R. Moore and D. Paty and M. Cynader},
  journal={The American journal of pathology},
  volume={162 5},
  • Bing Zhu, L. Luo, +2 authors M. Cynader
  • Published 2003
  • Biology, Medicine
  • The American journal of pathology
  • Evidence has shown that excitotoxicity may contribute to the loss of central nervous system axons and oligodendrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE). Because dendrites and synapses are vulnerable to excitotoxicity, we examined these structures in acute and chronic models of EAE. Immunostaining for microtubule-associated protein-2 showed that extensive dendritic beading occurred in the white matter of the lumbosacral spinal cord (LSSC) during acute EAE… CONTINUE READING
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