Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

@article{ikov2014DendriticSD,
  title={Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease},
  author={Zuzana {\vS}i{\vs}kov{\'a} and Daniel Justus and Hiroshi Kaneko and Detlef Friedrichs and Niklas Henneberg and Tatjana Beutel and Julika Pitsch and Susanne Schoch and Albert Becker and Heinz von der Kammer and S. Maurel Remy},
  journal={Neuron},
  year={2014},
  volume={84},
  pages={1023-1033}
}
Dendritic structure critically determines the electrical properties of neurons and, thereby, defines the fundamental process of input-to-output conversion. The diversity of dendritic architectures enables neurons to fulfill their specialized circuit functions during cognitive processes. It is known that this dendritic integrity is impaired in patients with Alzheimer's disease and in relevant mouse models. It is unknown, however, whether this structural degeneration translates into aberrant… CONTINUE READING
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