Dendritic Spines Prevent Synaptic Voltage Clamp

@article{BeaulieuLaroche2018DendriticSP,
  title={Dendritic Spines Prevent Synaptic Voltage Clamp},
  author={Lou Beaulieu-Laroche and Mark T. Harnett},
  journal={Neuron},
  year={2018},
  volume={97},
  pages={75-82.e3}
}
Synapses are the fundamental units of information processing in the mammalian brain. Much of our understanding of their functional properties comes from voltage-clamp analysis, the predominant approach for investigating synaptic physiology. Here, we reveal that voltage clamp is completely ineffective for most excitatory synapses due to spine electrical compartmentalization. Under local dendritic voltage clamp, single-spine activation produced large spine head depolarizations that severely… CONTINUE READING

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