Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells

@inproceedings{Brandalise2016DendriticNS,
  title={Dendritic NMDA spikes are necessary for timing-dependent associative LTP in CA3 pyramidal cells},
  author={Federico Brandalise and Stefano Carta and Fritjof Helmchen and John E. Lisman and Urs Gerber},
  booktitle={Nature communications},
  year={2016}
}
The computational repertoire of neurons is enhanced by regenerative electrical signals initiated in dendrites. These events, referred to as dendritic spikes, can act as cell-intrinsic amplifiers of synaptic input. Among these signals, dendritic NMDA spikes are of interest in light of their correlation with synaptic LTP induction. Because it is not possible to block NMDA spikes pharmacologically while maintaining NMDA receptors available to initiate synaptic plasticity, it remains unclear… CONTINUE READING