Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors

@article{Schuler1997DendriticCA,
  title={Dendritic Cells as Adjuvants for Immune-mediated  Resistance to Tumors },
  author={Gerold Schuler and R M Steinman},
  journal={The Journal of Experimental Medicine},
  year={1997},
  volume={186},
  pages={1183 - 1187}
}
T he Problem: Tumor Immunity Is Not Effectively Induced in Tumor-bearing Hosts. Animal experiments as well as clinical experience, notably in melanoma, indicate that the immune system can recognize and kill tumor cells. In particular , CTLs recognize MHC class I–peptide complexes on the tumor cell surface, and the peptides are derived from nonmutated or mutated genes that can be primarily expressed in the tumors (1–3). Why then does the immune system fail to eradicate most antigenic cancers… CONTINUE READING

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Cunning on Jne 24

D. I. Gabrilovich, H. I. Chen, H.T.K.R. Girgis
D ow nladed fom Published October • 1997
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