Dendritic Cells Take up and Present Antigens from Viable and Apoptotic Polymorphonuclear Leukocytes

@inproceedings{Alfaro2011DendriticCT,
  title={Dendritic Cells Take up and Present Antigens from Viable and Apoptotic Polymorphonuclear Leukocytes},
  author={Carlos Alfaro and Natalia Su{\'a}rez and Carmen O{\~n}ate and Jose Luis Perez-Gracia and Ivan Martinez-Forero and Sandra Herv{\'a}s-Stubbs and Inmaculada Mateo Rodr{\'i}guez and Guiomar P{\'e}rez and Elixabet Bola{\~n}os and As{\'i}s Palaz{\'o}n and Miguel Fernandez de Sanmamed and Aizea Morales-Kastresana and {\'A}lvaro Gonzalez and Ignacio Melero},
  booktitle={PloS one},
  year={2011}
}
Dendritic cells (DC) are endowed with the ability to cross-present antigens from other cell types to cognate T cells. DC are poised to meet polymorphonuclear leukocytes (PMNs) as a result of being co-attracted by interleukin-8 (IL-8), for instance as produced by tumor cells or infected tissue. Human monocyte-derived and mouse bone marrow-derived DC can readily internalize viable or UV-irradiated PMNs. Such internalization was abrogated at 4°C and partly inhibited by anti-CD18 mAb. In mice, DC… CONTINUE READING