Dendritic Cells Cross-Present Latency Gene Products from Epstein-Barr Virus–Transformed B Cells and Expand Tumor-Reactive Cd8+ Killer T Cells

@article{Subklewe2001DendriticCC,
  title={Dendritic Cells Cross-Present Latency Gene Products from Epstein-Barr Virus–Transformed B Cells and Expand Tumor-Reactive Cd8+ Killer T Cells},
  author={Marion Subklewe and Casper Paludan and Ming Li Tsang and Karsten Mahnke and Ralph Marvin Steinman and Christian M{\"u}nz},
  journal={The Journal of Experimental Medicine},
  year={2001},
  volume={193},
  pages={405 - 412}
}
Dendritic cells (DCs) are not targets for infection by the transforming Epstein-Barr virus (EBV). To test if the adjuvant role of DCs could be harnessed against EBV latency genes by cross-presentation, DCs were allowed to process either autologous or human histocompatibility leukocyte antigen (HLA)-mismatched, transformed, B lymphocyte cell lines (LCLs) that had been subject to apoptotic or necrotic cell death. After phagocytosis of small numbers of either type of dead LCL, which lacked direct… CONTINUE READING