Dendritic Cells As Inducers of Peripheral Tolerance.

  title={Dendritic Cells As Inducers of Peripheral Tolerance.},
  author={Courtney A Iberg and Andrew T Jones and Daniel Hawiger},
  journal={Trends in immunology},
  volume={38 11},
Mechanisms of tolerance initiated in the thymus are indispensable for establishing immune homeostasis, but they may not be sufficient to prevent tissue-specific autoimmune diseases. In the periphery, dendritic cells (DCs) play a crucial tolerogenic role, extending the maintenance of immune homeostasis and blocking autoimmune responses. We review here these essential roles of DCs in orchestrating mechanisms of peripheral T cell tolerance as determined by targeted delivery of defined antigens to… CONTINUE READING
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